導演：羅布·康 

主演：艾倫·旁派 吳珊卓 賈斯汀·錢伯斯 錢德拉·威爾森 小詹姆斯·皮肯斯 莎拉·拉米爾茲 Sara Ramirez 帕特里克·德姆西 Patrick Dempsey 埃裡克·迪恩 凱樂·利 Chyler Leigh 

The fifth-year residents return for the first day of a year that will make or break their careers Meredith faces the consequences of tampering with Derek's clinical trial and is terminated at the hospital; April tries to step up to the plate as Chief Resident in the wake of a giant sinkhole in the middle of Seattle; and Cristina and Owen are still at odds over their drastically different feelings for their unborn child.